The Science and Pervasiveness of Laboratory Animal Allergy

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The science and pervasiveness of laboratory animal allergy.

A llergic reactions to animals are among the most common conditions that adversely affect the health of workers involved in the care and use of animals in research (NRC 1997). Of the 90,000 laboratory animal workers in the United States (Bland et al. 1987), up to 46% develop allergy to laboratory animals. Of those who develop symptoms, more than 10% eventually develop occupationrelated asthma w...

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Laboratory animal allergy: an update.

Allergic reactions are among the most common conditions affecting the health of workers involved in the care and use of research animals. Between 11 and 44% of the individuals working with laboratory animals report work-related allergic symptoms. Of those who become symptomatic, 4 to 22% may eventually develop occupational asthma that can persist even after exposure ceases. Allergic symptoms co...

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Mechanism and epidemiology of laboratory animal allergy.

Laboratory animal allergy (LAA) is a form of occupational allergic disease. The development of laboratory animal allergy is due to the presence of IgE antibodies directed against animal proteins. The process of sensitization (development of IgE antibodies) is a complex process which involves interaction of antigen presenting cells and lymphocytes of the Th-2 cell type. These cells generate a ho...

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Smoking, atopy, and laboratory animal allergy.

This study examined data from three cross sectional surveys of 296 laboratory workers exposed to small mammals. Four indices of laboratory animal allergy were studied: symptoms suggestive of occupational asthma, symptoms suggestive of any occupational allergy, skin weals to animal urine extracts, and serum binding in radioallergosorbent tests with urine extracts. Pooled data from the three surv...

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ژورنال

عنوان ژورنال: ILAR Journal

سال: 2001

ISSN: 1084-2020

DOI: 10.1093/ilar.42.1.1